Although there is no correlation between FOXM1 and FOXO3 expression, there was a significant inverse correlation between the expression levels of FOXO3 and UBE2C, suggesting that FOXM1 and FOXO3 may be disputing for the binding to the FKHD responsive elements within UBE2C promoter region in ESCC. This evidence concerns the gene UBE2C and esophageal squamous cell carcinoma.