APC and pancreatic neoplasm: PDACs do not normally harbor mutations in classical Wnt regulators such as the adenomatous polyposis coli gene, APC. Yet, activating mutations of β-catenin, a downstream signaling partner for Wnt and loss-of-function mutations of APC have been observed in other pancreatic tumors including pancreatoblastomas [2], acinar cell carcinomas [3] and solid pseudo papillary tumors [4].