The neuroprotective effects of PACAP have been described not only in models of ischemic injuries, but also in neurodegenerative diseases [17], such as models of Parkinson’s disease [25,112], striatal model of Huntington’s disease [113] or spinobulbar muscular atrophy [114] and also in traumatic brain injury [115]. This evidence concerns the gene ADCYAP1 and Parkinson disease.