PAK3 and cervical carcinoma: In addition, recent research shows that PAK3 and SGK2 play key roles in the survival of HPV+ cervical cancer cells, while the lethality of PAK3 and SGK2 shRNAs for HPV+ cervical cancer cells has nothing to do with suppressing PAK3 or SGK2 expression but likely is exerted through non-specific RNAi effects [36].