KCNJ10 and epilepsy: Kir4.1 is a risk factor gene for epilepsy (Bockenhauer et al., 2009; Dai et al., 2015; Inyushin et al., 2010; Lenzen et al., 2005; Scholl et al., 2009), raising the possibility that Kir4.1 dysfunction in oligodendrocytes is sufficient to increase seizure susceptibility and induce death.