In addition, heterologous expression of Kir4.1 in glioma cells induces hyperpolarization and G1 arrest, an effect nullified if cells are treated with BaCl2 to block Kir4.1 or artificially depolarized by high K+ (Higashimori and Sontheimer, 2007). The gene discussed is KCNJ10; the disease is central nervous system cancer.