Polymorphisms in the Kir4.1 gene are associated with idiopathic epilepsy (Buono et al., 2004; Heuser et al., 2010; Lenzen et al., 2005) and autism spectrum disorder with seizures (Sicca et al., 2011; 2016), futher supporting a close functional link between Kir4.1 dysfunction and neuronal hyperexcitability. The gene discussed is KCNJ10; the disease is autism spectrum disorder.