In addition, polymorphisms in KCNJ10 are risk factors for epilepsy in humans (Buono et al., 2004; Dai et al., 2015; Guo et al., 2015; Lenzen et al., 2005), and seizures are a prominent component of the human disorder SeSAME/EAST syndrome, which results from loss-of-function mutations in KCNJ10 (Bockenhauer et al., 2009; Scholl et al., 2009). This evidence concerns the gene KCNJ10 and epilepsy.