Several spontaneously arising rodent models of epilepsy were found to have altered Kir4.1 levels (Harada et al., 2013; Nagao et al., 2013), and a single-nucleotide polymorphism in the Kir4.1 gene (kcnj10) was found to be responsible for differences in seizure susceptibility between C57BL6 and DBA/2 mice (Ferraro et al., 2004; Inyushin et al., 2010). This evidence concerns the gene KCNJ10 and epilepsy.