INS and early-onset autosomal dominant Alzheimer disease: IDE can effectively degrade insulin, amylin, and glucagon, pancreatic hormones that control blood glucose levels, as well as amyloid β (Aβ), a peptide implicated in Alzheimer’s disease (Duckworth et al., 1998; Kurochkin et al., 2018; Pivovarova et al., 2016; Tang, 2016; Tundo et al., 2017).