2010), (2) interstitial phosphate deposition has been implicated as a contributing pathogenic factor in renal fibrosis, and (3) TRPV5 is a gatekeeper protein for active renal calcium reabsorption in the kidney (Oddsson et al. 2015; Nie et al. 2016; Shen et al. 2016). Here, TRPV5 is linked to renal fibrosis.