GNRH1 and precocious puberty: Central precocious puberty (CPP, also known as gonadotropin-releasing hormone [GnRH]-dependent precocious puberty) is defined as premature activation of the hypothalamic-pituitary-gonadal axis and the development of secondary sexual characteristics in girls before 8 years of age and in boys before 9 years of age.[1] The CPP in the absence of an identifiable cause is termed idiopathic CPP (ICPP); with improvements in the standards of living, the incidence of ICPP has increased in recent years.