However, some cases of autoimmune diseases in patients with GD1 have been reported as autoimmune hemolytic anemia,[8] antiphospholipid syndrome,[9] lupus, and immune thrombocytopenia.[10] The accumulation of lipids in GD cells is associated with an inflammatory state, an activation of macrophages, and cytokine secretion.[11,12] Some of these interleukins, including interleukin-6, interleukin-1, interleukin-10, or interleukin-2 receptor, are associated with immune-system hyperactivity and related to the development of monoclonal or polyclonal gammopathies. This evidence concerns the gene IL10 and antiphospholipid syndrome.