For example, Jang et al. (2009) pointed out that 0.1 μg/mL neoagarotetraose could reduce the melanin content in murine melanoma B16F10 cells and could inhibit tyrosinase activity in B16F10 cells and mushroom tyrosinase activity in vitro; thus, it is a potential skin-whitening agent. Here, TYR is linked to melanoma.