CCL2 and injury: However, in renal injury mouse models, circulating Fstl1 appeared to regulate the immune response: in a cisplatin nephrotoxicity model Fstl1 inhibits the synthesis of pro-inflammatory cytokines, like IL-1β [91], and in a subtotal nephrectomy model Fstl1 decreases TNF-α, IL-6, and MCP-1 (monocyte chemotactic protein-1) expression [92].