Although FSTL1 has a negative prognostic value with respect to HF, it was found that patients with end-stage HF who received a combination of a left ventricle assist device (LVAD) and pharmacological therapy, who had high levels of FSTL1 at the time of LVAD implantation, showed recuperation and recovery of ejection fraction [9]. The gene discussed is FSTL1; the disease is hydrops fetalis.