TGFβ, generally believed to be produced by cancer cells, could suppress the function of tumor-infiltration of both adaptive and innate immune cells (including CD4+ or CD8+ T cells, dendritic cells, natural killer cells, neutrophils, and macrophages), and thus cancer tissues are generally under an immunosuppressive microenvironment [5–7]. This evidence concerns the gene TGFB1 and neoplasm.