KMT2A and acute myeloid leukemia: For example, inhibitors of histone H3K79 methyltransferase DOT1L selectively inhibited the proliferation of MLL-rearranged cells by inducing cell differentiation and apoptosis (Daigle et al. 2011); histone demethylase LSD1 inhibitors can rescue the blocked AML cell differentiation and inhibit the colony growth of AML cells (Fiskus et al. 2014; Ishikawa et al. 2017; Sugino et al. 2017).