When compared to normal hematopoietic stem cells (HSCs), the expression levels of KDM6B mRNA were substantially higher in each type of AML samples, including AML with t(15;17) (n = 54), AML with inv(16)/t(16;16) (n = 47), AML with t(8;21) (n = 60), AML with t(11q23) (n = 43) and AML complex (n = 48), and highest KDM6B overexpression was observed in AML with t(8;21) translocation (Fig. 1a). Here, KDM6B is linked to acute myeloid leukemia.