TP53 and cancer: Still, deregulation of CRLs may not solely account for deregulated HIF-1α in cancer since HIF-1α levels are controlled by different signaling mechanisms, including regulation by the HSP90 pathway, the HIF-1 pathway and the MDM2-p53 mediated ubiquitination pathway (Rowbotham et al., 2014; Cassol and Mete, 2015; Masoud and Li, 2015).