BTRC and skin cancer: Further evidence linking β-TrCPs to skin cancer is the observation that degradation of IκBα and PDCD4 by β-TrCPs can contribute to the development of skin squamous carcinoma (Dorrello et al., 2006; Gu et al., 2007) while expression of a dominant negative β-TrCP in mouse epidermis confers skin proliferation and apoptosis resistance in response to UVB irradiation (Bhatia et al., 2011).