FBXW7 and neoplasm: FBXW7 mutations and deletions have been described in various type of tumor types including T-cell leukemia, stomach, pancreas, breast, colon, bladder, prostate cancer, gastric, and cholangiocarcinoma with T-cell leukemia and cholangiocarcima harboring the highest mutations rates of 31 and 35% respectively (reviewed in Cheng and Li, 2012; Zheng et al., 2016).