FBXW8 also promotes the degradation of the hematopoietic progenitor kinase 1 (HPK1), a member of mammalian STE20-like serine/threonine kinases that is lost in >95% pancreatic cancer via proteasome-mediated degradation (Wang et al., 2014). Here, MAP4K1 is linked to familial pancreatic carcinoma.