BTRC and skin cancer: Deregulation of the F-box and WD containing protein β-TrCP is associated with several cancers, including breast, colon, pancreatic, liver, gastric, and prostate (Frescas and Pagano, 2008), and both overexpression and mutations in β-TrCPs have been reported in gastric, prostate, breast, pancreas, colon liver, and skin cancer (reviewed in Zheng et al., 2016).