NPHS1 and nephrotic syndrome: The other rare forms of slit diaphragm-related proteins associated nephrotic syndrome include CD2-associated protein (CD2AP) (32), an adapter molecule that acts as a bridge between the slit diaphragm and the actin cytoskeleton, and transient receptor potential cation channel type 6 (TRPC6) (33), a non-selective calcium channel in foot processes that interacts with nephrin and podocin.