Mutations in ARHGAP24 encoding Rho GTPase-activating protein 24 cause familial AD SRNS in the second and third decades of life (48), whereas mutations in ARHGDIA encoding RhoGDP dissociation inhibitor α cause congenital nephrotic syndrome or SRNS within the first 2 years of life with associated neurological abnormalities (49). Here, ARHGAP24 is linked to familial nephrotic syndrome.