Inverted formin 2 (INF2) regulates actin polymerization and mutations in INF2 were reported to cause SRNS in adolescence and early adulthood, as well as in patients with Charcot–Marie–Tooth disease (characterized by peripheral neuropathy and FSGS on renal biopsy) (43, 44). The gene discussed is INF2; the disease is focal segmental glomerulosclerosis.