For instance, aldosterone-producing adenomas with KCNJ5 mutations are enriched in tumors that are predominantly composed of ZF-like clear cells (Figures 1A,B) that show higher CYP17A1 and CYP11B1 expression profiles and significantly lower expression profiles for CYP11B2 (11, 15–18). This evidence concerns the gene CYP17A1 and adenoma.