CTNNB1 and neoplasm: Heterogeneous age of onset, degree of hypercortisolism and tumor size depending on the underlying genetic mutation:–PRKACA-mutant ACAs tend to have ↓ tumor size, earlier age of onset, and more pronounced hypercortisolism–CTNNB1-mutant ACAs tend to have ↑tumor size and less pronounced hypercortisolism