In contrast, tumors that are composed predominantly of ZG-like compact cells (Figures 1C,D) are typically enriched in ATP1A1-, ATP2B3-, and CACNA1D-mutant aldosterone-producing adenomas that show increased and strong CYP11B2 expression and predominantly negative CYP11B1 or CYP17A1 expression profiles (11, 15–18). This evidence concerns the gene CYP11B2 and adenoma.