However, various aGPCRs have been associated with cancer development and progression including GPR133/ADGRD1, which is required for glioblastoma growth (14); GPR116/ADGRF5, which furthers breast cancer metastasis (12); and CD97/ADGRE5 seems to enhance tumor cell invasion in several human malignancies (111–114). This evidence concerns the gene ADGRD1 and breast cancer.