The matrix comprised the soluble extract of a murine sarcoma (which are supposed to preserve the biological factors for TME formation), a synthesized hydrogel (which offers mechanical support and injectability) as well as recombinant proteins of basic fibroblast growth factor (bFGF) aimed at enhancing angiogenesis.26 The prepared gel, carrying different types of XCC, was injected subcutaneously into mice to create the immunogenic enclave. This evidence concerns the gene FGF2 and sarcoma.