To validate this assumption, we obtained TH from the soluble extract of murine sarcoma (derived by the transplantation of S180 cell line), profiled its protein composition by liquid chromatography mass spectrometry (LC‐MS) (Data File 1, Figure S1, Table S1, Supporting Information) and tested its effects on the behavior of primary fibroblasts and macrophages. This evidence concerns the gene TH and sarcoma.