By multivariate logistic regression analysis, age remained an independent risk factor for thyroid abnormalities in patients with acromegaly (OR = 1.092; 95% confidence interval (CI), 1.034–1.154; p = 0.002), while the GH burden lost its significance (OR = 1.000; 95% CI, 1.000–1.001; p = 0.090). This evidence concerns the gene GH1 and Abnormality of the thyroid gland.