In another study, induction of IRF8 and repression of β-catenin was found upon arachidonate 15-lipoxygenase (15-LO) inhibition by PD146176 in K562 cells, implicating another mechanism where IRF8 may be involved in eradicating CML LSCs (65). The gene discussed is IRF8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.