PRMT5 and leukemia: Downregulation of Protein Arginine Methyltransferase 5 (PRMT5) led to compromised K-rasG12D-induced arginine methylation of p53 in FANCA deficient cells, thereby demonstrating an arginine methylation-dependent FA-p53 interaction, as forced expression of PRMT5 in FANCA−/− HSPCs prolonged oncogenic response and delayed leukemia development in irradiated recipient mice (119).