Many genes that are stably expressed in certain immune cell subsets and have been identified as potential MS risk genes from cohort studies, direct immune cell differentiation in MS patients such as NF-κB in PBMCs (102), IL2RA in GM-CSF+ memory Th cells (103), TYK2 (tyrosine kinase 2) in Th2 cells (104), EOMES/TBX21 in CD56+ NK cells (105), and ZMIZ1 in plasmacytoid DCs (106). This evidence concerns the gene TYK2 and myeloid sarcoma.