CYP27B1 and myeloid sarcoma: Some rare risk SNPs have been identified in vitamin D metabolism genes, such as rs118204009 in CYP27B1 (20) although this has not been confirmed in subsequent work (21), and rs117913124 in CYP2R1 (22), which may impact both the risk of vitamin D insufficiency and the risk to develop MS, a validation of these findings in other cohorts will be necessary.