While IL-10 can hamper antimycobacterial immunity during BCG immunization (51), recent evidence from Rhesus macaque infection models has suggested that CD4+ T-cells coexpressing a balance of pro- and anti-inflammatory cytokines are significantly associated with granuloma sterilization, possibly due to a reduction in “collateral damage” to the lung tissue (52). The gene discussed is IL10; the disease is Granuloma.