For example, syncytin-1 was upregulated in >75% of bladder urothelial carcinomas, increasing proliferation and viability of immortalized uroepithelial cells, and a recurrent single nucleotide substitution in ERVWE1 3′LTR was shown to drive the binding of c-myb transcription factor, possibly empowering syncytin-1 promoter activity in this malignancy (Yu et al., 2014). The gene discussed is ERVW-1; the disease is bladder transitional cell carcinoma.