Moreover, in leukemia cells expressing native Np9, the protein was shown to co-activate multiple leukemia-associated signaling pathways, inducing an aberrant upregulation of pERK, c-Myc and β-catenin and cleaving Notch1 with a subsequent decrease of Numb (Chen et al., 2013) (Table 2, Figure 6). Here, NOTCH1 is linked to leukemia.