Particularly, in neuroblastoma cell lines, the HERV-W Env transfection mediated an augmented phosphorylation of the activating transcription factor CREB (CRE-binding protein), leading to the hyperactivation of an ion channel (SK3, small conductance Ca2+- activated K+ channel protein 3) already known to be involved in neuron excitotoxicity and neurological diseases (Li et al., 2013). Here, ERVW-1 is linked to neuroblastoma.