A recent study showed that HML2 Env knockdown was able to inhibit hBC cell proliferation, migration and invasion; affecting various cellular networks playing key roles in cancerogenesis (EGFR, TGFB1, NF-κB, c-myc, and p53) and impairing tumor-associated gene expression (ras, p-RSK, and p-ERK) (Zhou et al., 2016) (Figure 6). This evidence concerns the gene CLEC10A and neoplasm.