ERVW-1 and colorectal carcinoma: Similarly, a HERV-H env in chromosome X was found to be highly expressed in a subset of gastrointestinal cancers (Wentzensen et al., 2007) and the putative Env peptides showed the ability to stimulate autologous cytolytic T lymphocytes, leading to INFγ production and lysis of colorectal carcinoma cells (Mullins and Linnebacher, 2012a).