Angiotensin converting enzyme-2 (ACE2) is a key regulatory enzyme of the renin-angiotensin system (RAS) as it catalyzes the conversion of angiotensin II (Ang II) to angiotensin 1–7 (Ang 1–7) the latter can bind the G-coupled protein Mas receptor inducing vasodilatation contrasting the effects of the binding of Ang II to its receptor AT-1 that promotes vasoconstriction and hypertension (Perlot and Penninger, 2013). The gene discussed is ACE2; the disease is Hypertension.