AGAP3 and cutaneous mastocytosis: Depending on the test used for screening, one out of two to three patients with positive serum CrAg had asymptomatic CM, a finding like in other cohorts in the southern part of Africa (Mfinanga et al., 2015; Longley et al., 2016), suggesting that systematic LPs should be performed for all asymptomatic CrAg positive patients as a strategy to timely diagnose CM.