This shows that genes containing conserved RELA, STATI, IRFI, NF-kappaB, PEND, HLF, REL, CEBPA, DI_2, and NFKB1 binding sites (Supplementary Figure 2) are indeed over-represented in cancer-related DEGs and this over-representation can be recuperated computationally. This evidence concerns the gene HLF and cancer.