Similarly, the AUC with 95% confidence intervals to assess the sensitivity and specificity of the biomarkers for colorectal adenoma diagnosis corresponded to 0.75 (0.70–0.80), 0.71 (0.66–0.77), and 0.64 (0.59–0.70) for adiponectin, IGF-1, and TNF-α, respectively. This evidence concerns the gene TNF and colorectal adenoma.