Through a meta-analysis on IGF-1 and colorectal adenoma, Yoon et al. (62) reported that circulating levels of IGF-1, IGFBP1, and IGF-1/IGFBP-3 ratio were not associated with a risk of occurrence of colorectal adenoma but IGF-1 was associated with increased risk of occurrence of advanced colorectal adenoma. The gene discussed is IGFBP3; the disease is colorectal adenoma.