RANBP2 is a protein playing an important role in the energy homeostasis of neuronal cells.<h4>Conclusion</h4>In any ADS occurring in the context of SCD and/or autoimmune condition, we recommend to slowly wean steroids and to closely monitor the patient after weaning to quickly treat any recurrence of neurological symptom with IVMP. This evidence concerns the gene RANBP2 and Schnyder corneal dystrophy.