On the other hand, impaired insulin action in peripheral organs results in a loss of sensitivity to insulin, termed insulin resistance that triggers fasting hyperglycemia, increased hepatic lipid synthesis, dyslipidemia, hypertension, cumulating in fat accumulation and increased adiposity in the long run, that are all associated with higher immune system activity levels (Boulangé et al., 2016). Here, INS is linked to metabolic syndrome.