Ghrelin suppressed the release of IL-6 and TNF-α in the peritoneal cavity (Wu et al., 2007a) and the lungs (Wu et al., 2007b) in a sepsis model and in the brain in a focal cerebral ischaemia model (Cheyuo et al., 2011) in rats through a mechanism that requires intact vagus nerves. This evidence concerns the gene GHRL and Sepsis.