It has been reported that the administration of T2 to streptozotocin-induced diabetic rats, eliciting a marked SIRT1 activation-dependent renoprotective action, strongly attenuated the diabetic nephropathy-associated increase in NF-kB p65 subunit acetylation/activation (Shang et al., 2013). The gene discussed is NFKB1; the disease is diabetic kidney disease.