Souza et al. (2014) and Prestes et al. (2009) showed an increase in MMP-2 activity induced by RT (12 weeks, 3 times per week) in an obesity model and hypoestrogenism in rat skeletal muscles, which indicates that mechanical loading exercise exerts important regulatory roles in ECM homeostasis and the remodeling of muscle fibers and local connective tissue. The gene discussed is MMP2; the disease is obesity disorder.