P2RY2 and colitis: Noteworthy, the pharmacological activation of P2Y2R via 2-thioUTP in a mouse model of DSS-induced colitis reduced the disease activity index and histological score values as well as a decrease in bacterial translocation to the spleen when compared with untreated mice, thus highlighting a protective role of P2Y2R in sustaining the remission phase in this experimental model of colitis (Degagne et al., 2013).