Western blotting analysis showed that MPT0B451 treatment resulted in decreases in pro-caspase 3, 8 and 9 and increases in cleaved forms of caspase 3, 7, 8, 9 and poly (ADP-ribose) polymerase (PARP) (Figures 6C,D) indicating that MPT0B451 can activate apoptotic pathway in both HL-60 and PC-3 cancer cells despite of with different efficiency. This evidence concerns the gene CASP3 and cancer.