HDAC6 and breast cancer: As the result of other studies, HDAC6 has highly expressed in various cancer types including leukemia, prostate carcinoma, colorectal carcinoma and breast cancer compared with normal tissue, and the results also confirmed the high level of HDAC6 in HL-60 and PC-3 cells (Parmigiani et al., 2008; Hackanson et al., 2012).