The PDE4-selective inhibitor, cilomilast, is demonstrated to be effective treatments for COPD (Ouagued et al., 2005), while the first PDE4-selective inhibitor, rolipram, decreases LPS-induced lung neutrophilia in rodent models (Miotla et al., 1998; Toward and Broadley, 2001). The gene discussed is PDE4A; the disease is chronic obstructive pulmonary disease.