To prevent CIN, co-administration of white blood cell growth factor such as the granulocyte colony-stimulating growth factor (G-CSF) is recommend with chemotherapy (Smith et al., 2015), and has shown benefit in patients with breast cancer who received chemotherapy (Holmes et al., 2002; Vogel et al., 2005; Agiro et al., 2016). This evidence concerns the gene CSF3 and breast carcinoma.