Targeted inhibition of HDAC using naturally occurring pharmacological agents such as benzoic acid and cinnamic acid derivatives, and synthetic SelSA were demonstrated to retard CRC cells in vitro and in animals (Ruefli et al., 2001; Sanmartín et al., 2012; Gowda et al., 2012; Anantharaju et al., 2017a; Salimi et al., 2017). Here, HDAC9 is linked to colorectal carcinoma.