The greatest reduction in 3xTg-AD nuclei relative protein abundance was that of hemoglobin subunit 1 beta (HBB1), which participates in iron and oxygen binding and in oxygen transport; to a lesser degree, in the peroxiredoxins PRDX6 and PRDX3, key players in cellular redox function and protection against oxidative injury. Here, PRDX6 is linked to Alzheimer disease.