Studies have shown that DYN1 interacts with Aβ and phosphorylated tau, which may lead to excessive mitochondrial fragmentation, mitochondrial and synaptic defects that may eventually cause neuronal damage and cognitive decline (Manczak et al., 2011; Manczak and Reddy, 2012; Shirendeb et al., 2012). This evidence concerns the gene MAPT and Mental deterioration.