We found that protein levels of SOD [Mn] (SODM), SOD [Cu-Zn] (SODC), peroxiredoxin-3 and peroxiredoxin-6 were significantly decreased in nuclei of 3xTg-AD vs. WT mice, results that suggest these four proteins are involved in an oxidative stress-mediated process in the hippocampus of AD mice. The gene discussed is SOD1; the disease is Alzheimer disease.