BLVRB and Alzheimer disease: There was substantially reduced relative abundance in 3xTg-AD mitochondria of biliverdin-IX beta reductase (BLVRB), a protein required for heme oxidation that releases free iron and is associated with the α-synuclein expression that accumulates in Parkinson disease (Scherzer et al., 2008) and other neurodegenerative disorders, including AD (Moussaud et al., 2014).