PTGS2 and epilepsy: The LOX pathway-derived metabolites of AA, 5(S)-HETE, 8(S)-HETE, 12(S)-HETE, 15(S)-HETE, 19(S)-HETE and 20-HETE, remained unaltered with epilepsy and upon PEA treatment (data not shown), indicating a specific role of COX-2 mediated inflammation induced by epilepsy.