To determine whether the effect of MCB-613 on p53-R175H mutant is specific to the ovarian cancer cell line TYK-Nu or mediated through a conserved mechanism, we tested the effect of MCB-613 on p53-R175H in TOV-112D (ovarian cancer) and SK-BR-3 (breast cancer) cells. This evidence concerns the gene TP53 and ovarian carcinoma.