CD274 and hepatocellular carcinoma: Also, the authors did not find any structural variation in the 3ʹUTRs of the PD-L1 gene from 371 samples with HCC, and there was no HBV integration within or near the PD-L1 gene in 118 samples of HBV-related HCC, suggesting that structural variations in 3ʹUTRs of the PD-L1 gene might at least not be the main regulatory mechanism for the high expression of PD-L1 in hepatocytes from HBV-related HCC.