CD274 and hepatocellular carcinoma: In this study, we found that the staining patterns of PD-L1 were highly correlated with HBsAg+ HCC subtype, which is consistent with our observation in HBV+hepatocytes of HBV-persistent mice (Supplementary Fig. 3) and the report from Xie Z who showed the correlation of in situ PD-L1 expression to HBV load in patients with CHB37.