Interestingly, similar to PD-L1, a negative correlation of SALL4 in the center tumor (P < 0.0001, R = -0.3980, Pearson’s correlation coefficients) (Fig. 3g) but not peritumor regions (P = 0.1227, R = -0.1340, Pearson’s correlation coefficients) (Fig. 3h) to OS was observed, demonstrating that patients with higher SALL4 expression in the center tumor regions manifested shorter OS (P < 0.0001, log-rank test) (Fig. 3i). The gene discussed is CD274; the disease is neoplasm.