We found that SALL4 expression was much higher in the center tumor regions than in peritumor regions, while the content of tumor infiltrating CD8+T cells in the center tumor regions were much lower than those in peritumor regions (Fig. 9a); though the number of total tumor infiltrating CD8+T cells in the center tumor regions was decreased, which is consistent with our former finding25, the content of PD-1+CD8+T cells was much higher in the center tumor regions than those in peritumor regions (Fig. 9a). The gene discussed is CD8A; the disease is neoplasm.