CD274 and neoplasm: We found that though miR-200a and miR-383 expressed higher in the center tumor regions than in peritumor regions (Supplementary Fig. 1a–c), neither disparities (Supplementary Fig. 1d–g) nor correlations (Supplementary Fig. 1h–n) of these two miRNAs with either PD-L1 or SALL4 expression from both the center tumor and peritumor regions were observed, except a positive correlation between PD-L1 and miR-200a in the peritumor regions (Supplementary Fig. 1o), indicating these negative correlations between miR-200 family and SALL4 or PD-L1 are more specific for miR-200c.