Since the prognostic efficacy of PD-L1 has already been demonstrated in several human cancers, and the negative correlations of SALL4 to miR-200c and miR-200c to PD-L1 in HCC were identified by us as above, we evaluated the potential prognostic value of SALL4 and miR-200c in the center tumor regions. This evidence concerns the gene CD274 and cancer.