For the expression pattern of PD-L1 in HBV+HCC patients, as shown in Figs 1, 2, and Supplementary Fig. S3, according to the morphology and size of PD-L1+ cells, we observed that PD-L1 was mainly expressed on hepatocytes in the center tumor regions, while it mainly expressed on bone-marrow-derived cells in peritumor regions and in regions with liver cirrhosis. This evidence concerns the gene CD274 and cirrhosis of liver.