CD274 and neoplasm: Notably, although SALL4, PD-L1, and miR-200c significantly increased, these three molecules experienced extreme disparity, with a much higher SALL4 or PD-L1 expression and a relatively lower miR-200c in the center tumor regions when compared with those in peritumor regions, while SALL4 and PD-L1 were paralleled in expression (Fig. 1f), raising the possible close relations among SALL4, miR-200c, and PD-L1 during HCC progression.