We further determined that miR-200c can directly target the 3ʹ-UTR of PD-L1, and that miR-200c mimics could decrease the PD-L1 expression by HBV+hepatoma cells but miR-200c inhibitors could increase it by using a naturally HBV-infected HCC cell line, a recently established and solidly verified one20. Here, CD274 is linked to hepatocellular carcinoma.