One of the most dramatic changes in transcription was TNFSF10, which exhibited a ~2.3-fold increase after 3 days exposure to vitamin C. TNFSF10 encodes the TNF-related apoptosis-inducing ligand (TRAIL), a potent inducer of apoptosis that is a therapeutic target in many types of cancer including breast cancer18. This evidence concerns the gene TNFSF10 and cancer.