Linkage studies conducted in families with ET have reported mutations in ETM2 (essential tremor monogenetic locus 2) and (fused in sarcoma) FUS, while other studies have linked (leucine-rich repeat and Ig domain containing 1) LINGO1, FUS and teneurin transmembrane protein 4 (TENM4) with ET3. The gene discussed is EDN3; the disease is essential thrombocythemia.