Two polymorphic LRRK2 variants rs7133914 (R1398H) and rs7308720 (N551K), both in linkage disequilibrium, were previously reported to confer up to 20% reduction in risk of PD in Chinese patients5, the protective effect of which has been replicated in other Asian cohorts5,6. This evidence concerns the gene LRRK2 and Parkinson disease.