Although several other studies have demonstrated a “pathogenic” role for CD4+ or CD8+ T-cells with a less severe AKI in the absence of these cells23–26, we, on the other hand, surprisingly demonstrated that CD4+ or CD8+ T-cells depletion aggravated AKI after 5 days of AA injection with an increase in pCr, BUN and tubular necrotic lesions. The gene discussed is CD4; the disease is acute kidney injury.