In the spontaneous tumor model, most myeloid cell populations (CD45+ CD11b+ Ly6G+ Ly6C+ MHCIIlow/G-MDSC, CD45+ CD11b+ Ly6G+ Ly6C− MHCIIhigh/Mature Granulocytes, CD45+ CD11b+ Ly6G− Ly6C+/Mo-MDSC as defined in23) and total number of TAMs (CD45+ CD11b+ Ly6G− Ly6C− F4/80+ MHCII+) present in primary MMTV-PyMT tumors+/− Snail1 were not significantly different (Fig. 2a). The gene discussed is ITGAM; the disease is neoplasm.