NUP210 and primary biliary cholangitis: There is no good evidence that the AMA titre correlates with the course of PBC (although it can fall with treatment),90 but some groups have suggested specific anti-nuclear antibodies may delineate subtypes of PBC (gp210 with progressive disease and centromere antibodies with portal hypertensive phenotypes).76 128 129 This, however, remains to be validated widely.