Findings from studies including small numbers of patients provide evidence that if treatment with one anti-TNF agent becomes ineffective switching to a different anti-TNF agent could prove to be clinically beneficial.87 113 116 122 The efficacy and safety of adalimumab was evaluated in in 26 children with JIA resistant to current therapy (disease-modifying drugs in 17 cases and anti-TNF agents in 9 cases). The gene discussed is TNF; the disease is juvenile idiopathic arthritis.