CYP7A1 and neoplasm: In addition to tumor-induced systemic inflammation and hepatomegaly (Fig. 4) (Egeblad et al., 2010; Fearon et al., 2012; McAllister and Weinberg, 2014), hepatic expression of cyp7a1, the gene encoding the rate-limiting enzyme for synthesizing bile acids/alcohol (Kuipers et al., 2014; Thomas et al., 2008), tended to be decreased at as early as 5-7 dpf in tumor-bearing larvae (Fig. 6B-K).