Data revealed that genes encoding bile transporters (slc10a2 and slc10a4), the G protein-coupled bile acid receptor (gpbar1), Farnesoid X receptors (FXRs; nr1h4 and nr1h5) and known FXR targets (insig2 and apoa1b) (Wang et al., 2008) responded differently to the intestinal tumor. Here, INSIG2 is linked to intestinal neoplasm.