SERPINE1 and cancer: The SASP is characterized by the secretion of factors including growth hormones, cytokines, angiogenic factors, and extracellular matrix‐remodeling proteases (e.g. GROa1, IL‐6, IL‐8, and PAI‐1) that affect tissues locally and systemically, thereby accelerating or suppressing cancer development or other age‐associated conditions like atherosclerosis 1, 7, 17, 18.