Accordingly, we proposed that MPT0B098 inhibits hypoxia-induced EMT in HNSCC by (1) suppressing HIF-1α expression, (2) inhibiting the EMT-activating transcription factors Twist and SNAI2/Slug, (3) blocking TGF-β/Smad signaling, and (4) interfering with FAK-mediated actin cytoskeleton rearrangement (Fig. 9). This evidence concerns the gene HIF1A and head and neck squamous cell carcinoma.